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inflammation is the cause of restless legs syndrome
"Reducing internal inflammation can be as easy as removing the irritants. It is almost like removing a splinter from the skin. While the splinter is there, the body will create more and more inflammation until the splinter is pushed out. As soon as the splinter is gone, the healing process can begin. Toxins and waste products are irritating to the body. Decreasing the toxins brought into the body and assisting the body in eliminating waste products can lead to a reduction in pain and inflammation.1

Mounting evidence suggests that inflammation, a part of the immune response implicated in diseases such as cancer, Alzheimer's and diabetes, may also help translate stress into high blood pressure."2

1. Wendy Hodsdon, ND, "Natural Health Tips To Reduce Pain From Inflammation" The Diet Channel, Golden Heart Center for Wellness, Portland, OR

2. Medical College of Georgia (2006, December 30). "Inflammatory Genes Linked To Salt-sensitive Hypertension." ScienceDaily. Retrieved April 17, 2011, from /releases/2006/12/061227195238.htm

picture header of alcohol's relationship to RLS inflammation "Alcohol is known to promote inflammation, and alcohol use increases cytokines (which are substances produced by the liver cells and the immune system in response to infection or cell damage)."

June Russell "Deception in Reporting About Alcohol's Benefits."

"Alcohol causes inflammation of the stomach, pancreas, and intestines which impairs the digestion of food and absorption into blood. Moreover, the acetaldehyde (the oxidation product) can interfere with the activation of vitamins."

Charles E. Ophardt, "Alcohol Metabolism Effects." Virtual Chembook, Elmhurst College, Elmhurst, IL (2003).

"Alcohol is discouraged because it increases inflammation. Tendons and other areas typically inflamed by Repetitive Strain Injury (RSI) only get worse if you drink Alcohol."

Bill Gottlieb, "Alternative Cures: The Most Effective Natural Home Remedies for 160 Health Problems." Rodale Books, Emmaus, PA (October 15, 2000).

picture header of caffeine's relationship to RLS inflammation "People suffering from short-term inflammation may prolong their condition by drinking coffee and tea that contain caffeine."

J. Travis "Mice Reveal the Off Switch for Inflammation". Science News. (17 Apr, 2011).

"Habitual coffee consumption is associated with heightened acute vascular inflammatory responses to mental stress."

Dmitry N. Mayorov, Mark Hamer, Emily D. Williams, Raisa Vuononvirta, Leigh E. Gibson and Andrew Steptoe. "Association Between Coffee Consumption and Markers of Inflammation and Cardiovascular Function During Mental Stress." Journal of Hypertension. Lippincott Williams & Wilkins, Hagerstown, MD. ISSN 0263-6352 2006, vol. 24, no11.

"In summary, acting as A2AR antagonist, caffeine consumption may enhance acute liver inflammation. We suggest a possibility that caffeine might worsen the acute phase of viral hepatitis and drug-induced hepatic damage (i.e., acetaminophen hepatotoxicity). Future clinical and epidemiological studies may be necessary to determine whether the use of caffeine should be influenced by the knowledge of an individual's status of inflammation."

Akio Ohta2, Dmitriy Lukashev, Edwin K. Jackson, Bertil B. Fredholm and Michail Sitkovsky. "Trimethylxanthine (Caffeine) May Exacerbate Acute Inflammatory Liver Injury by Weakening the Physiological Immunosuppressive Mechanism." The Journal of Immunology, 2007, 179, 7431-7438.

picture header of gluten's relationship to RLS inflammation "Gluten is inflammatory and inflammation has been linked to most chronic illnesses and pain syndromes."

Ralph Havens, PT, OCS, IMTC, "Gluten and Inflammation." Mission Hills Physical Therapy: Wellness Blog, San Diego, CA (May 2, 2011)

"Researchers now know that gluten can cause inflammation in any organ and any cell of your body."

Claudia Pillow and Annalise Roberts. "Recognizing Gluten Sensitivity: Inflammation The Food Philosopher." Southlake, TX (2002)

"While going gluten free will greatly relieve inflammation, you must make additional dietary changes to fully relieve the symptoms."

Mallory Ferland "Gluten-Free, Anti Inflammatory Diets." Seattle, WA (September 2011)

picture header of insomnia's relationship to RLS inflammation "Loss of sleep, even for a few short hours during the night, can prompt one's immune system to turn against healthy tissue and organs. A new article in the September 15th issue of Biological Psychiatry, by the UCLA Cousins Center research team, reports that losing sleep for even part of one night can trigger the key cellular pathway that produces tissue-damaging inflammation. The findings suggest a good night's sleep can ease the risk of both heart disease and autoimmune disorders such as rheumatoid arthritis."

Michael R. Irwin, Minge Wang, Denise Ribeiro, Hyong Jin Cho, Richard Olmstead, Elizabeth Crabb Breen, Otoniel Martinez-Maza and Steve Cole. "Sleep Loss Activates Cellular Inflammatory Signaling" Biological Psychiatry, Volume 64, Issue 6 (September 15, 2011), published by Elsevier.

"New research has proven conclusively that the molecule known as adenosine is in charge of your feeling of sleepiness and is required in adequate amounts in order for you to fall asleep in a natural way. During the day, a great deal of adenosine is channeled in the direction of making ATP and making your brain stay awake and function. The longer you stay up the greater the amount of inflammation that starts to ramp up in your nerves, and the greater the urge to go to sleep."

Byron J. Richards, CCN, "Sleep Desire, Caffeine, and Inflammation." Wellness Resources, Inc. (February 18, 2011)

"Insomnia is the direct result of hormonal imbalance usually caused by inflammation, and there are several ways this can happen. You, like 50% of all Americans who have inflammation, can have intestinal tract inflammation from the over-use of anti-inflammatory drugs or antibiotics, or systemic inflammation in your bloodstream from eating foods that cause inflammation such as fast food, processed food, sodas, wheat or corn."

Richard Weinstein, "Insomnia = Inflammation & Stress." Source Energy Online Newsletter. Carson City, NV, (October 31, 2011).

picture header of msg's relationship to RLS inflammation "The injection of monosodium glutamate (MSG) in ICR mice leads to the development of significant inflammation, central obesity and type 2 diabetes."

Y. Nakanishi, K. Tsuneyama, M. Fujimoto, TL Salunga, K. Nomoto, JL An, Y. Takano, S. Iizuka, M. Nagata, W. Suzuki, T. Shimada, M. Aburada, M. Nakano, C. Selmi and ME Gershwin. "Monosodium Glutamate (MSG): A Villain and Promoter of Liver Inflammation and Dysplasia." Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. 2011 Feb-Mar;30(1-2):42-50.

"One theory holds that bacteria and viruses may cause this inflammation but clearly we know that lead, mercury, monosodium glutamate (MSG) and fluoride and other toxic chemicals can also cause inflammatory reactions in blood vessels."

Staff. "Inflammation and Systemic Stress: Inflammation and Pain Management with Magnesium." International Medical Veritas Association,

"Both adrenalectomized rats and adrenalectomized, MSG-treated rats showed an increased response to carrageenin relative to controls. These results suggest that glucocorticoids are important modulators of inflammation in this phase of the process."

EA Limaos, VL Silveira and MS Dolnikoff. "Inflammatory Edema Induced by Carrageenin in Monosodium Glutamate-Treated Rats." Braz-J-Med-Biol-Res. (1988) 21(4): 837-9

picture header of salt's relationship to RLS inflammation "Too much sodium can lead to high blood pressure, arthritis and inflammation. According to Drs. Ohtsuka and Sanderson of St. Bartholomew's and the Royal London School of Medicine and Dentistry, one type of sodium (DSS) even "induces an inflammatory bowel disease-like colitis in animals."

Tracey Allison Planinz, "Diet for Inflammation."

"A high sodium/potassium ratio is associated with specific symptoms including acute stress inflammation, and at times symptoms associated with zinc and/or magnesium deficiency.

We recommend restricting salt in individuals with a high sodium/potassium ratio, especially if the blood pressure is elevated. However, it is not usually necessary to eliminate all salt from the diet. Also, sea salt is often tolerated better than table salt because it has more magnesium and other trace elements. We do not recommend eating table salt, as it is missing its trace minerals and often has aluminum or other toxic metals added to it."

Newsletters & Health News, "Understanding A High Sodium/Potassium Ratio." Analytical Research Laboratories, Inc., Phoenix, AZ

"High sodium intake increases the serum concentration of inflammation and oxidative stress marker."

JM Gallardo, M. de Carmen Prado-Uribe, D. Amato D and R. Paniagua, "Inflammation and Oxidative Stress Markers by Pentoxifylline Treatment in Rats with Chronic Renal Failure and High Sodium Intake." - U.S. National Library of Medicine. Arch Med Res. (2007 Jan);38(1):34-8.

picture header of sugar's relationship to RLS inflammation "One of the biggest offenders of inflammation is ingestion of sugar. By sugar I mean table sugar, brown sugar, raw sugar, turbinado sugar, honey (even raw), maple sugar, corn sweetener, dextrose, glucose, fructose and any other word that ends in an "ose", barley malt, rice syrup, liquid cane sugar, concentrated fruit juice and others. Don't be fooled by the name organic when it applies to sugar. Sugar is sugar, organic or not."

Nancy Appleton, Ph.D.,"The Relationship between Sugar and Inflammation." LowCarb Monthly Magazine. (2007).

"The faster the foods show up as sugar in our blood, the faster inflammatory responses occur. This is dangerous for a diabetic, but slow or fast, the inflammation is destructive to all of us. High blood sugar damages the nervous system, the blood vessels, (which then get "repaired" by cholesterol deposits), and since our blood vessels go everywhere in our body, every part of our brain and body gets gradually eroded. Name a disease, it is related to this process."

Dianne M. Buxton, "Shocker - Sugar and Inflammation Make Life Less Sweet." (July 8, 2011)

"The study shows that high glucose can increase levels of key proteins that result in inflammation. The inflammation process in blood vessels and the kidney can lead to a build-up of cells (atherosclerosis) and damage to tissues that can constrict the passage of blood through vessels."

Armen Hareyan, "The Pathway Linking High Glucose to Inflammation That Can Cause Diabetes Complications."

Williams MD, Nadler JL. "Inflammatory Mechanisms of Diabetic Complications." Eastern Virginia Medical School. Current Diabetes Reports. 2007 Jun;7(3):242-8.

picture header of wheat's relationship to RLS inflammation "Bread, cereals and products made of corn or cereals also increase the inflammation response, especially if they contain wheat. Wheat causes a special type of inflammation in the intestines called celiac disease in some individuals, but may also trigger inflammation of non-celiac type."

Nathan Wei, MD, FACP, FACR. "Wheat and Joint Pain." (2004)

"Anyone suffering from celiac disease knows how inflammatory wheat can be."

Marcelle Pick, OB/GYN NP, "Causes of inflammation." Women to Women Clinic, Yarmouth, ME,

"Inflammation is one of the common denominators of disease. Every chronic disease is an inflammatory disease. No matter what so-called disease you have, from cancer to the common cold, inflammation is a major part of your problem.

Allergies and food sensitivities create inflammatory responses. Chronic allergic reactions create chronic inflammation. This is why allergic reactions must be minimized by strengthening the immune system and avoiding allergens. These dangerous drugs disrupt gut tissue, causing leakage of undigested food molecules into the blood, thereby promoting food allergies. A good idea for almost anyone is to stay away from the most common allergens such as dairy and wheat."

Raymond Francis, "Inflammation: A Common Denominator of Disease." Well Being Journal, Carson City, NV (November/December 2011).

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